Endocrine Abstracts

Introduction: Perrault syndrome is a rare autosomal recessive disorder defined by the association of 46XX ovarian dysgenesis and neurosensory deafness. Other manifestations may be present, in particular cerebellar and/or peripheral neuronal degenerative disease. we report the case of Perrault syndrome in a 15-year-old Tunisian girl.Observation: A 15-year-old girl was referred to our department for pubertal delay. She had a congenital deafness and epileps...

Introduction: Gynecomastia is an enlargement of male breast glandular tissue caused by an imbalance of the hormones androgens and estrogens. It can be physiological at different stages of life (birth, adolescence, senescence), caused by medication or reveal a serious pathology. The aim of our study was to evaluate the characteristics of presentation, biochemical profile, and etiology of gynecomastia.Methods: A retrospective study was conducted at the end...

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women and its main symptoms are related to menstrual disorders and hyperandrogenism. The aim of our study was to evaluate the clinical and paraclinical profile of PCOS.Methods: We conducted a retrospective study that included 50 women, followed at endocrinology department’s consultations of Rabta Hospital in Tunis. Each patient underwent a clinical examin...

Introduction: Swyer syndrome is a rare sex development disorder characterized by pure 46 XY gonadal dysgenesis. It is associated with aberrations in testicular determination and differentiation leading to a female morphotype with presence of external and internal female genitalia, undifferentiated fibrous gonads, a male karyotype and hypergonadotropic hypogonadism. We present the case of a 46 XY adolescent female with complete gonadal dysgenesis diagnosed following her hospita...

Introduction: Hirsutism is described as excessive development of facial and body hair in women in androgen-dependent areas. Our aim was to determine the clinical and metabolic aspects of hirsutism and its relationship with the metabolic syndrome.Methods: We conducted a retrospective descriptive study at the endocrinology department of Rabta Hospital in Tunis. We recruited 100 women who presented with hirsutism between January 2009 and December 2020 Clini...

Introduction: Hypothyroidism is a common endocrine disease with reduced systemic metabolism and its treatment consists on hormonal supplementation. However, despite concurrent replacement therapy with high doses of L-thyroxin, some patients might be seen with clinical and biochemical evidence of hypothyroidism. We report a case of persistent hypothyroidism on high dose of levothyroxin.Case presentation: It was a 41-year-old female, with a history of recu...

Introduction: Dopamine agonists, mainly cabergoline and bromocriptine, represent the first-line treatment option in the management of prolactinomas. They allow prolactin normalization and tumor shrinkage. However, a subset of individuals with macroprolactinoma could exhibit a varying degree of resistance to dopamine agonists. The aim of this study was to determine the prevalence of dopamine agonist-resistance in patients with macroprolactinoma and to assess its predictive fact...

Introduction: Surgical treatment is indicated in patients with dopamine agonist-resistant macroprolactinoma. However, the resection of the tumor is usually partial because of fibrotic changes under long-term dopamine agonist therapy. Thus, early identification and management of patients at high risk of dopamine agonist resistance is crucial to a complete resection outcome and a better remission. The aim of this study was to develop a score predicting dopamine agonist resistanc...

Introduction: Statins are widely used to prevent cardiovascular diseases. Nonetheless, reducing cholesterol, the main substrate for steroidogenesis, may impair cortisol production. The aim of our study was to assess the effect of high dose statin therapy on cortisol and dehydroepiandrosterone-sulphate (DHEA-S) levels in type 2 diabetes male patients.Methods: This was a single-center, prospective study, during the period march 2021 - July 2022, including ...

Introduction: Statins are widely used in primary and secondary cardiovascular prevention. They have been described to improve renal function. We aimed in this study to evaluate the effect of high dose atorvastatin therapy on renal outcome in type 2 diabetes patients.Methods: This was a single-center, prospective study, including 60 men with type 2 diabetes mellitus, aged between 40 and 65 years, statin-free, in whom the indication of a high dose statin t...